Early replication fragile sites: where replication–transcription collisions cause genetic instability
نویسندگان
چکیده
منابع مشابه
Early replication fragile sites: where replication-transcription collisions cause genetic instability.
Although it is known that replication stress causes genetic instability, the underlying mechanisms are not yet fully understood. A new study by Barlow et al (2013) used an elegant genome-wide chromatin immunoprecipitation approach to reveal that DNA lesions induced by replication stress occur predominantly in early replicating and actively transcribed gene clusters. These ‘early replication fra...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2013
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2013.20